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The fungus is capable of causing disseminated infection in immunocompetent hosts and is endemic to distinct geographic regions.
When infected, 99% of immunocompetent patients are asymptomatic after low inoculum exposure.
Five of the six reviews reported a statistically significant reduction in pneumococcal pneumonia and bacteraemia among immunocompetent adults who were not otherwise at increased risk.
Routine revaccination of immunocompetent persons previously vaccinated with 23-valent polysaccharide vaccine is not recommended.
Included in the patient population were immunocompetent adults receiving ventilatory support in hospital or long-term care settings.
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