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Sustained pain relief can be achieved with long-acting preparations, such as sustained-release oxycodone, morphine preparations or transdermal fentanyl.
Allan and colleagues compared transdermal fentanyl to sustained-release oral morphine in patients with noncancer chronic pain in a large, multicenter, two-way, crossover trial.
The first phase of the study demonstrated that the ascending dose that mirrored a sustained-release preparation was similar to the standard three-times-per-day dosage of methylphenidate.
Free nicotinic acid content was close to 500 mg per pill in the immediate- and sustained-release preparations.
Once a patient's pain has started to stabilize and an effective daily dose can be estimated, immediate - release preparations can be converted to sustained-release preparations.
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