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Clearly, such a rise in genetic diversity may also have important phenotypic implications, such as the emergence of viruses with altered antigenicity, virulence, or tissue tropism .
It has a wide cell tropism and remains extra-chromosomal, therefore minimising the risk of insertional mutagenesis.
This protein is embedded in and extends exterior to the viral lipid membrane and is primarily responsible for host cell receptor binding and host cell tropism .
Our data demonstrate that factors in addition to the amount of PrP expressed determine the tropism of prions for certain tissues.
An envelope glycoprotein on the surface is thought to be responsible for mediating viral entry into cells, tissue tropism , and host range.
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