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Several candidates have been suggested as the zeitgebers for peripheral clocks, including glucocorticoids, retinoic acid and melatonin.
All zeitgebers mirror the cycle length of the earth's rotation and they therefore shaped circadian systems as they evolved.
Scientists call external time cues zeitgebers .
The major zeitgebers pertinent to athletic performance include diet, daylight and temperature, exercise, social interactions, and drugs.
Future studies will be required to answer these important questions, as well to identify the major zeitgebers affecting the circadian clock of the heart.
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