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Heparin is a glycosaminoglycan whose major anticoagulant effect is accounted for by a pentasaccharide with a high affinity for antithrombin III.
In the initial phase of these titrations the peptide was much in excess over the added glycosaminoglycan .
Two other glycosaminoglycans , namely heparin and chondroitin sulfate B, were also studied with isothermal titration calorimetry.
This matrix consists of a network of structural and adhesive proteins embedded in a gel of glycosaminoglycans and proteoglycans.
Coumarin drugs, such as warfarin as well as the glycosaminoglycans , heparin and heparan sulfate, are useful as anticoagulants.
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