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Both lead to the release of mast cell and basophil immune mediators.
Furthermore, our observations suggest that a prominent mast cell reaction seems more related to pattern and nuclear grade I carcinomas than to poorly differentiated neoplasms.
This compound is employed as a classic mast cell secretagogue that releases histamine.
Some patients feel better after taking aspirin or a nonsteroidal anti-inflammatory drug, probably because mast cell degranulation releases prostaglandins and leukotrienes.
We have no explanation for this difference, but it is possible that allergen caused release of mast cell proteases and this might have cleaved the cytokine.
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