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Stimulation of osteogenesis leading to bone repair, as in patients with large bone defects, fracture non-unions, and incomplete allograft consolidation, is clinically desirable for early healing and restoration of function.
Platelet concentrates also have the potential to improve fracture healing and enhance osteogenesis .
Although both groups exhibit very similar chondrogenic patterns of the tarsus, only the amphibian pattern is preserved through osteogenesis .
As a consequence, the mineralized septa providing the scaffold for bone deposition cannot be formed, and osteogenesis itself is severely disturbed.
Inflammation is a necessary step in the healing of normal body tissues, and osteoblasts specifically require prostaglandins for osteogenesis and differentiation.
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