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With the exception of the relatively rare high penetrance , single gene disorders, genetic tests differ little from most other medical tests, providing evidence of statistical risk only.
Because of reduced penetrance , individuals of different genotypes can have the same phenotype.
High penetrance susceptibility genes probably account for no more than 5-10% of cases.
However, other low penetrance susceptibility genes may exist which may alter individual predisposition to breast cancer.
The penetrance of these phenotypes was background dependent.
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