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A genetic basis to the disorder is borne out by risk increasing with genetic proximity to the proband .
Furthermore, all these approaches are unable to handle trios with missing genotypic information on the proband and these families are typically excluded from the analysis.
Only offspring of both parents were included in the analysis, but birth order was defined by using all the mother's offspring, including both full and half siblings of the study proband .
Our study was a family-based study and included probands with asthma from two populations, Puerto Ricans and Mexicans.
Most data sets utilized in the study of hereditary diseases are constructed around probands , making correction for ascertainment bias necessary; this set of data is no exception.
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