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This phenomenon is attributed to platelet-aggregating factors and procoagulants from the tumor or its necrotic products.
Chemotherapy acts by killing leukemic cells, which release procoagulants that can produce disseminated intravascular coagulation.
Taipan venom is overwhelmingly neurotoxic, including pre and post-synaptic neurotoxins, as well as powerful procoagulants and myolysins.
The exudate, procoagulants , and leukocytes form casts in the airways, resulting in poor gas exchange.
When nitric oxide is deficient or used inadequately, endothelium becomes a procoagulant instead of an anticoagulant, and vasoactive molecules, cytokines, and growth factors are formed.
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