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The classical concept of the source of cardiac rhythm is that it originates from the sino-atrial node.
This activity arises not from excitatory nerve fibres, but spontaneously within the heart itself from a small clump of pacemaker cells near the point where the vena cava joins the right atrium: the sino-atrial node.
Procoralan exclusively reduces heart rate by a specific action on the sino-atrial node.
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