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Our data demonstrate that factors in addition to the amount of PrP expressed determine the tropism of prions for certain tissues.
It has a wide cell tropism and remains extra-chromosomal, therefore minimising the risk of insertional mutagenesis.
An envelope glycoprotein on the surface is thought to be responsible for mediating viral entry into cells, tissue tropism , and host range.
This protein is embedded in and extends exterior to the viral lipid membrane and is primarily responsible for host cell receptor binding and host cell tropism .
Clearly, such a rise in genetic diversity may also have important phenotypic implications, such as the emergence of viruses with altered antigenicity, virulence, or tissue tropism .
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