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These parameters are influenced by the plasma clearance, volume of distribution and bioavailability of the drug.
Systemic bioavailability secondary to lung bioavailability definitely occurs, but the contribution is insignificant.
These effects may profoundly affect the oral bioavailability of drugs.
Chapter sixteen has been written from the viewpoint of establishing bioavailability and bioequivalence of drugs and formulations.
Clinicians and patients should beware of possible reductions in systemic bioavailability of conventional drugs when taken concomitantly with St John's wort.
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