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The de novo assembly of silent chromatin requires passage through the S phase of the cell cycle.
Under normal conditions equal amounts of the four core histones are incorporated into chromatin .
The structure of chromatin is intimately linked to the function of the eukaryotic genome.
The eukaryotic chromatin must be highly organized to fit into the small volume of the nucleus.
Indeed the Polycomb protein has been detected in inactive chromatin isolated from the bithorax complex.
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