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The hallmark of muscular dystrophy is that muscle cells die due to a lack of the muscle protein dystrophin .
Muscle-generating stem cells can improve muscle regeneration and deliver the missing protein dystrophin to damaged muscles in a mouse muscular dystrophy model, according to a recent study.
Our results suggest that the different binding modes of dystrophin may be regulated more by the structural state of the actin filament than by the isoform involved.
However, in vitro studies have failed to detect any bundling of actin by either intact dystrophin or Dys - 246.
It too is caused by insufficient production of dystrophin .
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