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Medications that can reduce androgen levels include estrogen, gonadotropin-releasing hormone agonists, and glucocorticoids .
Some steroid hormones, such as glucocorticoids , bind to a cytoplasmic receptor protein that is then translocated into the nucleus.
In one of them, Dallman and her colleagues simulated chronic stress by increasing the brain concentration of a rodent version of the glucocorticoid called cortisol.
Exogenous glucocorticoid may compensate for the reduced concentrations of cortisol, except at times of metabolic stress, when the extra demand for cortisol cannot be met by the atrophied adrenal glands.
If signs and symptoms of glucocorticoid , mineralocorticoid, adrenal sex hormone, or catecholamine excess are present, surgery is usually indicated.
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