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There are recommendations about the target levels for glycaemia , blood pressure, and lipids in the treatment of patients with type 2 diabetes.
Also, the effects of glycaemia and albuminuria, as well as of high density lipoprotein cholesterol, triglycerides, and electrocardiographic findings, could be taken into account, providing a more valid risk table.
Firstly, the relation between glycaemia and incidence of diabetes is non-linear, with the risk threshold coinciding with the onset of pre-diabetes.
The only identified source of heterogeneity was a tendency for trials with a longer duration to be associated with a larger difference in control of glycaemia between pump and injection therapy and a smaller difference in insulin dosage.
Efforts should therefore be made to normalise glycaemia when diabetes is first diagnosed.
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