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Oral pilocarpine is contraindicated in patients with uncontrolled asthma and in patients in whom miosis is undesirable, such as patients with acute iritis or narrow angle (angle closure) glaucoma.
Although miosis was the most common symptom, severely poisoned patients developed CNS symptoms and cardiomyopathy.
A stimulant action on the parasympathetic portion of the oculomotor nucleus (third cranial nerve) is responsible for pupillary miosis .
After inhalation of vapour, respiratory symptoms, dimming of vision, and miosis are generally the first clinical features to appear.
Symptoms include nasal congestion, ptosis of one eyelid, miosis , and conjunctional hyperemia.
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