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The maintenance phase consisted of ‘Agarol’ (active ingredients: liquid paraffin, phenolphthalein , benzoic acid, and sorbic acid) 5-30 ml once or twice daily, senna granules, or bisacodyl tablets.
The non-osmotic laxatives, phenolphthalein and senna, partly act by stimulating secretory mechanisms in the intestine.
Bromthymol blue changes from yellow at pH 4 to blue around pH 7, and phenolphthalein changes from colorless at pH 7 to pink at pH 9.
The listing is based on findings from feeding studies of phenolphthalein that caused cancer in multiple organs in multiple species of experimental animals.
In fact, one popular laxative ingredient was taken off the market because scientists found ‘clear evidence of carcinogenic activity’ in laboratory animals exposed to phenolphthalein .
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