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Clinical trials of new antipruritic agents are in progress.
Topical application of doxepin provides significant antipruritic activity with a favorable safety profile, suggesting a role for doxepin cream in the symptomatic treatment of pruritus associated with eczematous dermatitis.
Diphenhydramine, in a dosage of 25 to 50 mg three or four times daily, or hydroxyzine hydrochloride, in a dosage of 25 mg three or four times daily, provides an antipruritic effect.
Several studies have shown that the serotonergic effect of selective serotonin reuptake inhibitors consistently produces the strongest antipruritic response in patients with neurotic excoriations.
These compounds have anti-inflammatory, antipruritic and vasoconstrictive properties.
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