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Adults with cystic fibrosis are susceptible to hypoxemia, hypercapnia , arousal from sleep, and neurobehavioral impairment.
We also computed the number of spikes discharged in each respiratory cycle, at each level of hypercapnia .
Baseline ventilation was normal, and the respiratory and cardiovascular responses to hyperoxic hypercapnia were normal in the patients.
These effects include a mild degree of hypoventilation with consequent hypercapnia , and a diminished responsiveness to respiratory stimuli.
During a relapse, respiratory muscle weakness can precipitate hypoxemia and hypercapnia of rapid onset.
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