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Most women with the syndrome experience menarche at a normal age but have irregular menstrual periods that gradually become more abnormal, often leading to amenorrhea.
The longer a woman's fertile life (the interval between the menarche and the menopause), the more likely she will develop Parkinson's disease.
But the delayed menarche and the delayed puberty may have an effect on their growth and height.
age at menarche varies considerably between populations
The findings have important implications, as the age of menarche - when menstruation begins - has fallen by two years in the past century.
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