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In addition, these ligands markedly upregulated production of CD36, a scavenger receptor that regulates phagocytosis of apoptotic neutrophils.
Weakened resistance to infection is caused by decreased antibody and complement production, leukocyte phagocytosis and intracellular killing, and macrophage phagocytosis .
Fc receptors mediate various effects on immune cells, including proliferation of B cells and phagocytosis by phagocytes.
Destruction of the red cells occurs as a result of the red cell-bound autoantibodies to the Fc receptors on monocytes and macrophages; phagocytosis and cytotoxic lysis of the red cells subsequently occur.
During phagocytosis , monocytes, neutrophils and macrophages generate Superoxide radicals, hydrogen peroxide and the highly reactive hydroxyl radicals3.
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