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DeWitte and colleagues also recently demonstrated that HYP is a photoactive anticancer agent in A431 skin tumor cell xenografts , and basal cell carcinoma and squamous cell carcinoma in patients.
Another small preclinical study demonstrated improved tumor response for human rectal-carcinoma xenografts treated with PDT under hyperbaric oxygen.
In this report, we show that such targeted agents are transported across respiratory epithelia lining human tracheal xenografts , and its transcytosis paralleled expression of hpIgR.
However, we were able to examine the transport of the anti-hSC Fv-based fusion proteins from the circulation to the lumenal surface of human epithelia in tracheal xenografts .
Intratumoral injected methylene blue plus red light illumination was also effective against human colon tumor xenografts , with destruction of 75% of tumors after a single treatment.
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