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Diphenhydramine, in a dosage of 25 to 50 mg three or four times daily, or hydroxyzine hydrochloride, in a dosage of 25 mg three or four times daily, provides an antipruritic effect.
Moreover, the profound antipruritic effect of this drug is an added benefit.
Clinical trials of new antipruritic agents are in progress.
This itching cannot be fully suppressed by conventional antipruritic agents such as antihistamines, and development of effective drugs has long been awaited.
Topical application of doxepin provides significant antipruritic activity with a favorable safety profile, suggesting a role for doxepin cream in the symptomatic treatment of pruritus associated with eczematous dermatitis.
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