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Each hydrogen bond between molecules is much weaker than the covalent bonds holding the atoms together within the molecule.
Compared to say, a covalent bond, a hydrogen bond is approximately one tenth of that strength.
The two electronegative atoms involved in a hydrogen bond are not bonded covalently; they are non-covalent, electrostatic partners.
Breaking a single hydrogen bond may impair the stability of a protein.
This is consistent with a structure that has lost the intramolecular hydrogen bond .
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