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It is hydroxylated to an active form in the liver, influenced by the level of serum calcium.
However, some children display slow hydroxylation and clear tricyclic antidepressants more slowly.
The ‘alternative’ pathway begins with the hydroxylation of the cholesterol side chain.
During phase I, functional groups are added to the drug, or existing functional groups are transformed through oxidation, reduction, hydroxylation , hydrolysis and so on.
Both women and men with lupus have been found to have increased concentrations of 16 - hydroxylated estrogens in the serum.
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