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The second subtype of switch-reference markers is found in many American Indian languages.
Although AChE has many variants from alternative splicing of a single gene in some species, the tetrameric subtype T is the only form expressed in the adult nervous system and muscles in mammals.
In the US and Europe, subtype B is still the predominant subtype in circulation, though the prevalence of non-B subtypes in increasing 13-16.
The most common subtype of melanoma, superficial spreading melanoma, may exhibit the ‘ABCDs’ of melanoma.
Within this broad category, there may be subtypes with distinct differences.
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