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A dense band of fibroblasts , collagen fibers, proteoglycans, and occasional mast cells encase the granuloma.
Its primary function is at sites of inflammation, where it is produced in macrophages, fibroblasts , and synovial cells.
The researchers also added connective tissue cells called fibroblasts to the mix as a crucial third ingredient.
Collagen is synthesized by fibroblasts , the living cells present in all connective tissue, so named because they generate fibres - of collagen.
This application of topical nitric oxide may stimulate wound fibroblasts to increase collagen synthesis and remodeling.
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