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Big, long, expensive programs against enzymes like elastase and thrombin went on year after year, but no one could get the things to quite work well enough.
Protective mechanisms prevent thrombin and other procoagulant enzymes from forming in healthy intact blood vessels.
In addition to its role in activation of fibrin clot formation, thrombin plays an important regulatory role in coagulation.
The thrombin cleaves fibrinogen to an active monomer that polymerizes to form a fibrin meshwork.
The blood-clotting cascade ends in the formation of a substance that converts a blood protein called prothrombin into the protein thrombin , which actually forms the substance of the blood clot.
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