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One piece with which Milne was pleased was his clarification of the tyramine monoamine-oxidase inhibitor interaction (the ‘cheese reaction’).
The phenolic substrates studied were p-cresol, p-hydroxyphenyl propionic acid, tyramine , and L- and D-tyrosine.
These could lead to serious interactions with foods containing tyramine , alcohol, narcotics, and over-the-counter decongestants.
About nine per cent of people have at least one copy of a gene for 5HT2a that call for the amino acid tyramine at one point in the receptor protein.
Foods high in arylalkylamines (tryptophan, tyrosine, tyramine , and phenylalanine) have also been implicated in triggering IC symptoms.
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